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Vickers, Anna, Mushtaq, Shazad, Woodford, Neil, Doumith, Michel and Livermore, David M 
ORCID: https://orcid.org/0000-0002-9856-3703
(2018)
Activity of RX-04 pyrrolocytosine protein synthesis inhibitors against multidrug-resistant gram-negative bacteria.
Antimicrobial Agents and Chemotherapy, 62 (8).
e00689-18.
ISSN 0066-4804
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Abstract
Pyrrolocytosines RX-04A-D are designed to bind to the bacterial 50S ribosomal subunit differently from currently-used antibiotics. The four analogs had broad anti-Gram-negative activity: RX-04A inhibited 94.7% of clinical Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa at 0.5-4 μg/ml, with no MICs >8 μg/ml. MICs for multi-resistant carbapenemase producers were up to two-fold higher than for control strains, with values ≥8 μg/ml for one Serratia isolate with porin and efflux lesions. mcr-1 did not affect MICs.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 28 Jun 2018 13:30 |
| Last Modified: | 21 Oct 2022 19:32 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/67480 |
| DOI: | 10.1128/AAC.00689-18 |
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