Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

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Hagenaars, Saskia P., Radaković, Ratko, Crockford, Christopher, Fawns-Ritchie, Chloe, Harris, Sarah E., Gale, Catharine R. and Deary, Ian J. (2018) Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function. PLoS One, 13 (6). ISSN 1932-6203

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Abstract

Neurodegenerative disorders are associated with impaired cognitive function and worse physical health outcomes. This study aims to test whether polygenic risk for Alzheimer’s disease, Amyotrophic Lateral Sclerosis (ALS), or frontotemporal dementia (FTD) is associated with cognitive function and physical health in the UK Biobank, a cohort of healthy individuals. Group-based analyses were then performed to compare the top and bottom 10% for the three neurodegenerative polygenic risk scores; these groups were compared on the cognitive and physical health variables. Higher polygenic risk for AD, ALS, and FTD was associated with lower cognitive performance. Higher polygenic risk for FTD was also associated with increased forced expiratory volume in 1s and peak expiratory flow. A significant group difference was observed on the symbol digit substitution task between individuals with high polygenic risk for FTD and high polygenic risk for ALS. The results suggest some overlap between polygenic risk for neurodegenerative disorders, cognitive function and physical health.

Item Type: Article
Additional Information: Data Availability: Data from the UK Biobank (www.ukbiobank.ac.uk) are third party and legal constraints do not permit public sharing of the data. The UK Biobank data used in this study can be accessed by applying through the UK Biobank Access Management System (www.ukbiobank.ac.uk/register-apply). The data generated by the International FTD-Genomics Consortium (IFGC) are available upon request to protect patient information; the IFGC can be requested via https://ifgcsite.wordpress.com/data-access/ Funding information: The work was undertaken in The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross council Lifelong Health and Wellbeing Initiative (MR/K026992/1); funding from the BBSRC and Medical Research Council (MRC) is gratefully acknowledged. This report represents independent research part-funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. CC is supported by the Euan MacDonald Centre for Motor Neurone Disease Research. CF-R is supported by Dementias Platform UK (DPUK), funded through the MRC (MR/L023784/2).
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life
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Depositing User: LivePure Connector
Date Deposited: 22 Jun 2018 15:30
Last Modified: 13 Aug 2024 09:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/67429
DOI: 10.1371/journal.pone.0198187

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