Impact of stroke‐associated pneumonia on mortality, length of hospitalization, and functional outcome

Teh, W. H., Smith, C. J., Barlas, R. S., Wood, A. D., Bettencourt-Silva, J. H., Clark, A. B. ORCID: https://orcid.org/0000-0003-2965-8941, Metcalf, A. K., Bowles, K. M. ORCID: https://orcid.org/0000-0003-1334-4526, Potter, J. F. and Myint, P. K. (2018) Impact of stroke‐associated pneumonia on mortality, length of hospitalization, and functional outcome. Acta Neurologica Scandinavica, 138 (4). pp. 293-300. ISSN 0001-6314

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Abstract

Objectives: Stroke‐associated pneumonia (SAP) is common and associated with adverse outcomes. Data on its impact beyond 1 year are scarce. Materials and methods: This observational study was conducted in a cohort of stroke patients admitted consecutively to a tertiary referral center in the east of England, UK (January 2003‐April 2015). Logistic regression models examined inpatient mortality and length of stay (LOS). Cox regression models examined longer‐term mortality at predefined time periods (0‐90 days, 90 days‐1 year, 1‐3 years, and 3‐10 years) for SAP. Effect of SAP on functional outcome at discharge was assessed using logistic regression. Results: A total of 9238 patients (mean age [±SD] 77.61 ± 11.88 years) were included. SAP was diagnosed in 1083 (11.7%) patients. The majority of these cases (n = 658; 60.8%) were aspiration pneumonia. After controlling for age, sex, stroke type, Oxfordshire Community Stroke Project (OCSP) classification, prestroke modified Rankin scale, comorbidities, and acute illness markers, mortality estimates remained significant at 3 time periods: inpatient (OR 5.87, 95%CI [4.97‐6.93]), 0‐90 days (2.17 [1.97‐2.40]), and 91‐365 days (HR 1.31 [1.03‐1.67]). SAP was also associated with higher odds of long LOS (OR 1.93 [1.67‐2.22]) and worse functional outcome (OR 7.17 [5.44‐9.45]). In this cohort, SAP did not increase mortality risk beyond 1 year post‐stroke, but it was associated with reduced mortality beyond 3 years. Conclusions: Stroke‐associated pneumonia is not associated with increased long‐term mortality, but it is linked with increased mortality up to 1 year, prolonged LOS, and poor functional outcome on discharge. Targeted intervention strategies are required to improve outcomes of SAP patients who survive to hospital discharge.

Item Type:	Article
Uncontrolled Keywords:	acute stroke,mortality,prognosis,stroke‐associated pneumonia
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Population Health
Depositing User:	LivePure Connector
Date Deposited:	12 Jun 2018 16:30
Last Modified:	19 Oct 2023 02:13
URI:	https://ueaeprints.uea.ac.uk/id/eprint/67349
DOI:	10.1111/ane.12956

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