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Piddock, Rachel E., Marlein, Christopher R., Abdul-Aziz, Amina, Shafat, Manar S., Auger, Martin J., Bowles, Kristian M. 
ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A.
(2018)
Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC.
Journal of Hematology & Oncology, 11.
ISSN 1756-8722
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Abstract
Multiple myeloma (MM) remains an incurable malignancy despite the recent advancements in its treatment. The protective effects of the niche in which it develops has been well documented; however, little has been done to investigate the MM cell’s ability to ‘re-program’ cells within its environment to benefit disease progression. Here, we show that MM-derived macrophage migratory inhibitory factor (MIF) stimulates bone marrow stromal cells to produce the disease critical cytokines IL-6 and IL-8, prior to any cell-cell contact. Furthermore, we provide evidence that this IL-6/8 production is mediated by the transcription factor cMYC. Pharmacological inhibition of cMYC in vivo using JQ1 led to significantly decreased levels of serum IL-6—a highly positive prognostic marker in MM patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | myeloma,mif,cmyc,bmsc,stromali,l-6i,l-8,bone marrow |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 30 May 2018 17:30 |
| Last Modified: | 25 Sep 2024 13:27 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/67250 |
| DOI: | 10.1186/s13045-018-0614-4 |
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