Total synthesis of altissimacoumarin D, a small molecule sirtuin1 activator

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Silva, Anna C., Benelkebir, Hanae, Lopes, Rosangela S. C., Lopes, Claudio C. and Ganesan, A. (2018) Total synthesis of altissimacoumarin D, a small molecule sirtuin1 activator. Journal of the Brazilian Chemical Society, 29 (5). pp. 1157-1161. ISSN 0103-5053

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Abstract

The total synthesis of the plant natural product altissimacoumarin D was achieved by the Mitsunobu alkylation of isofraxidin by geraniol. Isofraxidin was prepared from 2,4-dihydroxybenzaldehyde in five steps. The key reaction was the Knoevenagel condensation of an ortho-hydroxybenzaldehyde with Meldrum’s acid under neutral conditions in water and one-pot acid catalyzed cyclization to the coumarin.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Related URLs:	http://jbcs.sbq.org.br/imagebank/pdf/201...
Depositing User:	Pure Connector
Date Deposited:	09 Apr 2018 14:30
Last Modified:	28 Mar 2025 08:39
URI:	https://ueaeprints.uea.ac.uk/id/eprint/66696
DOI:	10.21577/0103-5053.20180021

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