Total synthesis of altissimacoumarin D, a small molecule sirtuin1 activator

Silva, Anna C., Benelkebir, Hanae, Lopes, Rosangela S. C., Lopes, Claudio C. and Ganesan, A. ORCID: (2018) Total synthesis of altissimacoumarin D, a small molecule sirtuin1 activator. Journal of the Brazilian Chemical Society, 29 (5). pp. 1157-1161. ISSN 0103-5053

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The total synthesis of the plant natural product altissimacoumarin D was achieved by the Mitsunobu alkylation of isofraxidin by geraniol. Isofraxidin was prepared from 2,4-dihydroxybenzaldehyde in five steps. The key reaction was the Knoevenagel condensation of an ortho-hydroxybenzaldehyde with Meldrum’s acid under neutral conditions in water and one-pot acid catalyzed cyclization to the coumarin.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
UEA Research Groups: Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
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Depositing User: Pure Connector
Date Deposited: 09 Apr 2018 14:30
Last Modified: 04 Mar 2024 17:41
DOI: 10.21577/0103-5053.20180021


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