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ToolsSilva, Anna C., Benelkebir, Hanae, Lopes, Rosangela S. C., Lopes, Claudio C. and Ganesan, A. (2018) Total synthesis of altissimacoumarin D, a small molecule sirtuin1 activator. Journal of the Brazilian Chemical Society, 29 (5). pp. 1157-1161. ISSN 0103-5053
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Abstract
The total synthesis of the plant natural product altissimacoumarin D was achieved by the Mitsunobu alkylation of isofraxidin by geraniol. Isofraxidin was prepared from 2,4-dihydroxybenzaldehyde in five steps. The key reaction was the Knoevenagel condensation of an ortho-hydroxybenzaldehyde with Meldrum’s acid under neutral conditions in water and one-pot acid catalyzed cyclization to the coumarin.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
| UEA Research Groups: | Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 09 Apr 2018 14:30 |
| Last Modified: | 28 Oct 2025 00:48 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/66696 |
| DOI: | 10.21577/0103-5053.20180021 |
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