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Fragkos, Konstantinos C. and Forbes, Alastair 
ORCID: https://orcid.org/0000-0001-7416-9843
(2018)
Citrulline as a marker of intestinal function and absorption in clinical settings: A systematic review and meta-analysis.
United European Gastroenterology Journal, 6 (2).
pp. 181-191.
ISSN 2050-6406
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Abstract
Background: Citrulline has been described as a marker of intestinal function or absorption but evidence varies according to clinical settings. Objective: The objective of this article is to examine the evidence of plasma citrulline as a marker of intestinal function and absorption in various clinical settings. Methods: Studies were examined for p values, means and standard deviations, correlation coefficients or other metrics depicting the association of citrulline with intestinal function. A random effects model was used to produce a pooled estimate. A hierarchical summary receiver operating curve model was fitted for diagnostic accuracy measures. Results: Citrulline levels are correlated strongly with small bowel length in short bowel syndrome patients (r = 0.67). Citrulline is strongly negatively correlated (r = –0.56) with intestinal disease severity with regards to enteropathies (coeliac disease, tropical enteropathy, Crohn’s disease, mucositis, acute rejection in intestinal transplantation). Citrulline cut-off levels have an overall sensitivity and specificity of 80% and 84% respectively. Citrulline levels in untreated coeliac patients compared to controls were reduced by 10 µmol/l. Citrulline levels increase with gluten-free diet and with improvement of enteropathy. Citrulline is decreased in critical illness and sepsis. Conclusion: These findings allow us to advocate quite reasonably that citrulline is a marker of acute and chronic intestinal insufficiency.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | citrulline,meta-analysis,short bowel syndrome,enteropathy,systematic review |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 13 Mar 2018 15:30 |
| Last Modified: | 29 Sep 2023 09:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/66483 |
| DOI: | 10.1177/2050640617737632 |
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