Tools
Tools
Gasper, Amy, Hollands, Wendy, Casgrain, Amelie, Saha, Shikha, Teucher, Birgit, Dainty, Jack R. 
ORCID: https://orcid.org/0000-0002-0056-1233, Venema, Dini P., Hollman, Peter C., Rein, Maarit J., Nelson, Rebecca, Williamson, Gary and Kroon, Paul A.
(2014)
Consumption of both low and high (−)-epicatechin apple puree attenuates platelet reactivity and increases plasma concentrations of nitric oxide metabolites: A randomized controlled trial.
Archives of Biochemistry and Biophysics, 559.
pp. 29-37.
ISSN 0003-9861
Abstract
We hypothesised that consumption of flavanol-containing apple puree would modulate platelet activity and increase nitric oxide metabolite status, and that high flavanol apple puree would exert a greater effect than low flavanol apple puree. 25 subjects consumed 230 g of apple puree containing 25 and 100 mg epicatechin (low and high flavanol apple puree, respectively) and aspirin (75 mg) in random order. Measurements were made at baseline, acutely after treatment (2, 6 and 24 h), and after 14 d of treatment. Low flavanol apple puree significantly attenuated ADP and epinephrine-induced integrin-β3 expression 2 h and 6 h after consumption and ADP and epinephrine-induced P-selectin expression within 2 h of consumption. High flavanol apple puree attenuated epinephrine and ADP-induced integrin-β3 expression after 2 and 6 h. ADP and epinephrine-induced integrin-β3 expression was significantly attenuated 2, 6 and 24 h after consumption of aspirin, whilst 14 d aspirin consumption attenuated collagen-induced P-selectin expression only. The plasma total nitric oxide metabolite conc. was significantly increased 6 h after consumption of both low and high flavanol apple purees. In conclusion, consumption of apple purees containing ⩾25 or 100 mg flavanols transiently attenuated ex vivo integrin-β3 and P-selectin expression and increased plasma nitric oxide metabolite conc. in healthy subjects, but the effect was not enhanced for the high flavanol apple puree.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | platelet reactivity,nitric oxide,flavonoids |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Population Health |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 26 Feb 2018 15:30 |
| Last Modified: | 06 Jun 2024 15:00 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/66372 |
| DOI: | 10.1016/j.abb.2014.05.026 |
Actions (login required)
 |
View Item |