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ToolsSackley, Catherine M., Smith, Christina H, Rick, Caroline E, Brady, Marian C., Ives, Natalie, Patel, Smitaa, Woolley, Rebecca, Dowling, Francis, Patel (Parkinson's UK), Ramilla, Roberts, Helen, Jowett, Sue, Wheatley, Keith, Kelly, Debbie, Sands, Gina and Clarke, Carl E and PD COMM Pilot Collaborative Group (2018) Lee Silverman Voice Treatment versus standard speech and language therapy versus control in Parkinson’s disease: a pilot randomised controlled trial (PD COMM pilot). Pilot and Feasibility Studies, 4.
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Abstract
Background: Speech-related problems are common in Parkinson’s disease (PD), but there is little evidence for the effectiveness of standard speech and language therapy (SLT) or Lee Silverman Voice Treatment (LSVT LOUD®). Methods: The PD COMM pilot was a three-arm, assessor-blinded, randomised controlled trial (RCT) of LSVT LOUD®, SLT and no intervention (1:1:1 ratio) to assess the feasibility and to inform the design of a full-scale RCT. Non-demented patients with idiopathic PD and speech problems and no SLT for speech problems in the past 2 years were eligible. LSVT LOUD® is a standardised regime (16 sessions over 4 weeks). SLT comprised individualised content per local practice (typically weekly sessions for 6–8 weeks). Outcomes included recruitment and retention, treatment adherence, and data completeness. Outcome data collected at baseline, 3, 6, and 12 months included patient-reported voice and quality of life measures, resource use, and assessor-rated speech recordings. Results: Eighty-nine patients were randomised with 90% in the therapy groups and 100% in the control group completing the trial. The response rate for Voice Handicap Index (VHI) in each arm was ≥ 90% at all time-points. VHI was highly correlated with the other speech-related outcome measures. There was a trend to improvement in VHI with LSVT LOUD® (difference at 3 months compared with control: − 12.5 points; 95% CI − 26.2, 1.2) and SLT (difference at 3 months compared with control: − 9.8 points; 95% CI − 23.2, 3.7) which needs to be confirmed in an adequately powered trial. Conclusion: Randomisation to a three-arm trial of speech therapy including a no intervention control is feasible and acceptable. Compliance with both interventions was good. VHI and other patient-reported outcomes were relevant measures and provided data to inform the sample size for a substantive trial.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | parkinson’s disease,pilot randomised controlled trial,speech and language therapy |
| Faculty \ School: | Faculty of Medicine and Health Sciences > School of Health Sciences Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Rehabilitation |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 01 Feb 2018 11:30 |
| Last Modified: | 13 May 2023 00:26 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/66174 |
| DOI: | 10.1186/s40814-017-0222-z |
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