Semiautomatic assessment of the terminal ileum and colon in patients with Crohn disease using MRI (the VIGOR++ project)

Puylaert, Carl A.J., Schüffler, Peter J., Naziroglu, Robiel E., Tielbeek, Jeroen A. W., Li, Zhang, Makanyanga, Jesica C., Tutein Nolthenius, Charlotte J., Nio, C. Yung, Pendsé, Douglas A., Menys, Alex, Ponsioen, Cyriel Y., Atkinson, David, Forbes, Alastair ORCID: https://orcid.org/0000-0001-7416-9843, Buhmann, Joachim M., Fuchs, Thomas J., Hatzakis, Haralambos, van Vliet, Lucas J., Stoker, Jaap, Taylor, Stuart A. and Vos, Frans M. (2018) Semiautomatic assessment of the terminal ileum and colon in patients with Crohn disease using MRI (the VIGOR++ project). Academic Radiology, 25 (8). pp. 1038-1045. ISSN 1076-6332

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Abstract

Rationale and Objectives: The objective of this study was to develop and validate a predictive magnetic resonance imaging (MRI) activity score for ileocolonic Crohn disease activity based on both subjective and semiautomatic MRI features. Materials and Methods: An MRI activity score (the “virtual gastrointestinal tract [VIGOR]” score) was developed from 27 validated magnetic resonance enterography datasets, including subjective radiologist observation of mural T2 signal and semiautomatic measurements of bowel wall thickness, excess volume, and dynamic contrast enhancement (initial slope of increase). A second subjective score was developed based on only radiologist observations. For validation, two observers applied both scores and three existing scores to a prospective dataset of 106 patients (59 women, median age 33) with known Crohn disease, using the endoscopic Crohn's Disease Endoscopic Index of Severity (CDEIS) as a reference standard. Results: The VIGOR score (17.1 × initial slope of increase + 0.2 × excess volume + 2.3 × mural T2) and other activity scores all had comparable correlation to the CDEIS scores (observer 1: r = 0.58 and 0.59, and observer 2: r = 0.34–0.40 and 0.43–0.51, respectively). The VIGOR score, however, improved interobserver agreement compared to the other activity scores (intraclass correlation coefficient = 0.81 vs 0.44–0.59). A diagnostic accuracy of 80%–81% was seen for the VIGOR score, similar to the other scores. Conclusions: The VIGOR score achieves comparable accuracy to conventional MRI activity scores, but with significantly improved reproducibility, favoring its use for disease monitoring and therapy evaluation.

Item Type:	Article
Uncontrolled Keywords:	crohn disease,radiology,monitoring and evaluation,automation
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	Pure Connector
Date Deposited:	03 Jan 2018 07:28
Last Modified:	22 Oct 2022 03:26
URI:	https://ueaeprints.uea.ac.uk/id/eprint/65831
DOI:	10.1016/j.acra.2017.12.024

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