Vigorous intensity aerobic interval exercise in bladder cancer patients prior to radical cystectomy: a feasibility randomised controlled trial

Banerjee, Srijit, Manley, Kate, Shaw, Barnabas, Lewis, Liane, Cucato, Gabriel, Mills, Robert, Rochester, Mark, Clark, Allan and Saxton, John (2018) Vigorous intensity aerobic interval exercise in bladder cancer patients prior to radical cystectomy: a feasibility randomised controlled trial. Journal of Supportive Care in Cancer, 26 (5). 1515–1523. ISSN 0941-4355

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Abstract

Purpose: Strategies to improve pre-operative cardiopulmonary fitness could positively impact recovery aftersurgery. This study investigated the feasibility of pre-operative vigorous intensity aerobic interval exercise inbladder cancer patients prior to radical cystectomy (RC). Methods: A total of 60 patients were randomised (1:1)to an exercise or control group following a cardiopulmonary exercise test (CPET). The exercise group wasoffered twice-weekly pre-operative supervised vigorous intensity aerobic interval exercise in addition tostandard treatment, whilst the controls received standard treatment only. A repeat CPET was undertaken beforesurgery and post-operative recovery outcomes were recorded. Results: Over half of the 112 eligible patientsapproached in the clinic were recruited to the study (53.5%), with 52 of the 60 recruited patients (87%)attending both pre-operative CPETs and post-operative recovery data being available for 55 of the patients(92%). Patients attended a median of 8 (range: 1-10) exercise sessions over a pre-operative period of 3-6 weeks.Improvements in peak values of oxygen pulse (P=0.001), minute ventilation (P=0.002) and power output(P<0.001) were observed at the follow-up CPET in the exercise group versus controls and there were no adverseevents. Although this feasibility study was not powered to detect changes in post-operative recovery outcomes,there were marginal (non-significant) differences in favour of the exercise group in post-operative Clavien-Dindo score and need for High Dependency Unit inotropic support. Conclusions: Vigorous intensity aerobicinterval exercise could be an effective strategy for improving pre-operative physiological reserve and postoperativerecovery outcomes in bladder cancer patients undergoing RC. Implications for Cancer Survivors:Bladder cancer patients respond well to pre-surgical interval exercise and the improvements in cardiopulmonaryfitness variables could have important implications for post-operative recuperation after RC.

Item Type:	Article
Uncontrolled Keywords:	pre-operative care,exercise ,urinary bladder neoplasms,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Medicine and Health Sciences > School of Health Sciences Faculty of Medicine and Health Sciences > Allied Health Professions (former - to 2013)
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Centres > Population Health
Depositing User:	Pure Connector
Date Deposited:	06 Dec 2017 06:07
Last Modified:	06 Feb 2025 07:34
URI:	https://ueaeprints.uea.ac.uk/id/eprint/65686
DOI:	10.1007/s00520-017-3991-2

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