Preliminary biological evaluation and mechanism of action studies of selected 2-arylindoles against glioblastoma

Prabhu, Saurabh, Akbar, Zaheer, Harris, Frederick, Karakoula, Katherine, Lea, Robert, Rowther, Farzana, Warr, Tracy and Snape, Timothy (2013) Preliminary biological evaluation and mechanism of action studies of selected 2-arylindoles against glioblastoma. Bioorganic & Medicinal Chemistry, 21 (7). pp. 1918-1924. ISSN 0968-0896

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Abstract

A series of related 2-arylindoles have been evaluated for their anticancer activity against a range of glioblastoma cell lines using a number of different cell-based assays to determine cell viability after treatment with the compounds. The best indoles, which showed comparable activity to cisplatin against a U87MG cell line in the MTS assay, were taken forward and initial studies suggest that their mechanism of action is consistent with the generation of reactive oxygen species followed by autophagic cell death. Furthermore, activity was also observed in glioblastoma short-term cell cultures for the best lead compound and in some cases gave low micromolar IC50s.

Item Type:	Article
Additional Information:	Copyright © 2013 Elsevier Ltd. All rights reserved.
Uncontrolled Keywords:	2-arylindoles,glioblastoma,reactive oxygen species (ros),autophagy,cancer,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Pharmacy
Depositing User:	Pure Connector
Date Deposited:	09 Aug 2017 05:06
Last Modified:	22 Oct 2022 02:59
URI:	https://ueaeprints.uea.ac.uk/id/eprint/64420
DOI:	10.1016/j.bmc.2013.01.032

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