Associations between adding a radial artery graft to single and bilateral internal thoracic artery grafts and outcomes. Insights from the Arterial Revascularization Trial

Taggart, David P., Altman, Douglas G., Flather, Marcus D., Gerry, Stephen, Gray, Alastair M., Lees, Belinda and Benedetto, Umberto and ART Investigators (2017) Associations between adding a radial artery graft to single and bilateral internal thoracic artery grafts and outcomes. Insights from the Arterial Revascularization Trial. Circulation, 136 (5). pp. 454-463. ISSN 0009-7322

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Abstract

Background—Whether the use of the radial artery (RA) can improve clinical outcomes in coronary artery bypass graft (CABG) surgery remains unclear. The Arterial Revascularization Trial (ART) was designed to compare survival after bilateral internal thoracic artery (BITA) over single left internal thoracic artery (SITA). In the ART, a large proportion of patients (~20%) also received a RA graft instead of a saphenous vein graft (SVG). We aimed to investigate the associations between using the RA instead of SVG to supplement SITA or BITA grafts and outcomes by performing a post-hoc analysis of the ART.  Methods—Patients enrolled in the ART (n=3102) were classified based on conduits actually received (as treated). The analysis included 2737 patients who received a RA graft (RA group, n=632) or SVG only (SVG group, n=2105) in addition to SITA or BITA grafts. The primary endpoint was the composite of myocardial infarction, cardiovascular death and repeat revascularization at 5 years. Propensity score matching and stratified Cox regression were used to compare the two strategies.  Results—MI, cardiovascular death and repeat revascularization cumulative incidence was 2.3% (95%CI 1.1-3.4), 3.5% (95%CI 2.1-5.0) and 4.4% (95%CI 2.8-6.0) in the RA group and 3.4% (95%CI 2.0-4.8), 4.0% (95%CI 2.5-5.6) and 7.6% (95%CI 5.5- 9.7) in the SVG group respectively. The composite endpoint was significantly lower in the RA group (8.8%; 95%CI 6.5-11.0) when compared with the SVG group (13.6%; 95%CI 10.8-16.3) (P=0.005). This association was present when a RA graft was used to supplement both SITA and BITA grafts (interaction P=0.62).  Conclusions—This post-hoc ART analysis showed that an additional RA was associated with lower risk for mid-term major adverse cardiac events when used to supplement SITA or BITA grafts.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	Pure Connector
Date Deposited:	26 Jul 2017 05:04
Last Modified:	03 Nov 2022 15:43
URI:	https://ueaeprints.uea.ac.uk/id/eprint/64263
DOI:	10.1161/CIRCULATIONAHA.117.027659

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