Disruption of contralateral inferior parietal cortex by 1Hz repetitive TMS modulates body sway following unpredictable removal of sway-related fingertip feedback

Johannsen, Leif ORCID: https://orcid.org/0000-0002-2441-3163, Hirschauer, Franziska, Stadler, Waltraud and Hermsdörfer, Joachim (2015) Disruption of contralateral inferior parietal cortex by 1Hz repetitive TMS modulates body sway following unpredictable removal of sway-related fingertip feedback. Neuroscience Letters, 586. pp. 13-18. ISSN 0304-3940

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Abstract

Contact with an earth-fixed reference augments sway-related feedback and leads to sway reduction during upright standing. We investigated the effect of repetitive transcranial magnetic stimulation (rTMS) over the left hemisphere inferior parietal gyrus (IPG) as well as middle frontal gyrus (MFG) on the progression of sway following right-hand finger tip contact onset and removal. In two experimental sessions, 12 adults received 20 min of 1 Hz rTMS stimulation at 110% passive motor threshold over the left MFG and left IPG, respectively. Before and after each stimulation interval, participants' body sway was assessed in terms of antero-posterior Center-of-Pressure (CoP) velocity. Passive touch onset and removal were timed at random intervals by controlling the vertical position of a contact plate. Progression of sway was evaluated across 6s before to 6s after each contact event. Following both contact onset and removal, a temporary increase in sway above baseline without contact was observed. After removal overshoot was especially prominent. While steady-state sway was not altered by stimulation, rTMS over the left IPG reduced overshoot compared to pre-stimulation; thus, improving sway progression on haptic deprivation. We discuss our finding in the light of altered transient postural disorientation due to intermodal sensory conflict, illusion of backwards falling and tactile attention capture.

Item Type:	Article
Additional Information:	Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Uncontrolled Keywords:	tms,ipg,mfg,body sway,sensory reorganisation
Faculty \ School:	Faculty of Medicine and Health Sciences > School of Health Sciences
Depositing User:	Pure Connector
Date Deposited:	25 Jul 2017 05:09
Last Modified:	25 Sep 2024 12:52
URI:	https://ueaeprints.uea.ac.uk/id/eprint/64239
DOI:	10.1016/j.neulet.2014.11.048

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