Secretory leukoprotease inhibitor (Slpi) expression is required for educating murine dendritic cells inflammatory response following quercetin exposure

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De Santis, Stefania, Galleggiante, Vanessa, Scandiffio, Letizia, Liso, Marina, Sommella, Eduardo, Sobolewski, Anastasia, Spilotro, Vito, Pinto, Aldo, Campiglia, Pietro, Serino, Grazia, Santino, Angelo, Notarnicola, Maria and Chieppa, Marcello (2017) Secretory leukoprotease inhibitor (Slpi) expression is required for educating murine dendritic cells inflammatory response following quercetin exposure. Nutrients, 9 (7). ISSN 2072-6643

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Abstract

Dendritic cells’ (DCs) ability to present antigens and initiate the adaptive immune response confers them a pivotal role in immunological defense against hostile infection and, at the same time, immunological tolerance towards harmless components of the microbiota. Food products can modulate the inflammatory status of intestinal DCs. Among nutritionally-derived products, we investigated the ability of quercetin to suppress inflammatory cytokines secretion, antigen presentation, and DCs migration towards the draining lymph nodes. We recently identified the Slpi expression as a crucial checkpoint required for the quercetin-induced inflammatory suppression. Here we demonstrate that Slpi-KO DCs secrete a unique panel of cytokines and chemokines following quercetin exposure. In vivo, quercetin-enriched food is able to induce Slpi expression in the ileum, while little effects are detectable in the duodenum. Furthermore, Slpi expressing cells are more frequent at the tip compared to the base of the intestinal villi, suggesting that quercetin exposure could be more efficient for DCs projecting periscopes in the intestinal lumen. These data suggest that quercetin-enriched nutritional regimes may be efficient for suppressing inflammatory syndromes affecting the ileo-colonic tract.

Item Type: Article
Uncontrolled Keywords: quercetin,dendritic cells,slpi,inflammation
Faculty \ School: Faculty of Science > School of Biological Sciences
Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups: Faculty of Science > Research Groups > Molecular and Tissue Pharmacology
Related URLs:
Depositing User: Pure Connector
Date Deposited: 12 Jul 2017 05:06
Last Modified: 25 Sep 2024 12:51
URI: https://ueaeprints.uea.ac.uk/id/eprint/64084
DOI: 10.3390/nu9070706

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