Rapid Acquisition of the Transcranial Magnetic Stimulation Stimulus Response Curve

Mathias, Jonathan P, Barsi, Gergely I, van de Ruit, Mark and Grey, Michael J (2014) Rapid Acquisition of the Transcranial Magnetic Stimulation Stimulus Response Curve. Brain Stimulation, 7 (1). pp. 59-65. ISSN 1935-861X

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Abstract

BACKGROUND: Transcranial magnetic stimulation is frequently used to construct stimulus response (SR) curves in studies of motor learning and rehabilitation. A drawback of the established method is the time required for data acquisition, which is frequently greater than a participant's ability to maintain attention. The technique is therefore difficult to use in the clinical setting.  OBJECTIVE: To reduce the time of curve acquisition by determining the minimum acquisition time and number of stimuli required to acquire an SR curve.  METHODS: SR curves were acquired from first dorsal interosseous (FDI) and abductor digiti minimi (ADM) at 6 interstimulus intervals (ISI) between 1.4 and 4 s in 12 participants. To determine if low-frequency rTMS might affect the SR curve, MEP amplitudes were monitored before and after 3 min of 1 Hz rTMS delivered at 120% of resting motor threshold in 12 participants. Finally, SR curves were acquired from FDI, ADM and Biceps Brachii (BB) in 12 participants, and the minimum number of stimuli was calculated using a sequential MEP elimination process.  RESULTS: There were no significant differences between curves acquired with 1.4 s ISI and any other ISI. Low frequency rTMS did not significantly depress MEP amplitude (P = 0.87). On average, 61 ± 18 (FDI), 60 ± 16 (ADM) and 59 ± 16 (BB) MEPs were needed to construct a representative SR curve.  CONCLUSIONS: This study demonstrates that reliable SR curves may be acquired in less than 2 min. At this rate, SR curves become a clinically feasible method for assessing corticospinal excitability in research and rehabilitation settings.

Item Type: Article
Additional Information: Copyright © 2014 Elsevier Inc. All rights reserved.
Uncontrolled Keywords: corticospinal excitability,rtms,assessment,neuroplasticity
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
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Depositing User: Pure Connector
Date Deposited: 27 Jun 2017 05:06
Last Modified: 22 Apr 2020 04:58
URI: https://ueaeprints.uea.ac.uk/id/eprint/63848
DOI: 10.1016/j.brs.2013.08.003

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