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Mathias, Jonathan P., Barsi, Gergely I., van de Ruit, Mark and Grey, Michael J. 
ORCID: https://orcid.org/0000-0002-3216-3272
(2014)
Rapid acquisition of the transcranial magnetic stimulation stimulus response curve.
Brain Stimulation, 7 (1).
pp. 59-65.
ISSN 1935-861X
Abstract
BACKGROUND: Transcranial magnetic stimulation is frequently used to construct stimulus response (SR) curves in studies of motor learning and rehabilitation. A drawback of the established method is the time required for data acquisition, which is frequently greater than a participant's ability to maintain attention. The technique is therefore difficult to use in the clinical setting. OBJECTIVE: To reduce the time of curve acquisition by determining the minimum acquisition time and number of stimuli required to acquire an SR curve. METHODS: SR curves were acquired from first dorsal interosseous (FDI) and abductor digiti minimi (ADM) at 6 interstimulus intervals (ISI) between 1.4 and 4 s in 12 participants. To determine if low-frequency rTMS might affect the SR curve, MEP amplitudes were monitored before and after 3 min of 1 Hz rTMS delivered at 120% of resting motor threshold in 12 participants. Finally, SR curves were acquired from FDI, ADM and Biceps Brachii (BB) in 12 participants, and the minimum number of stimuli was calculated using a sequential MEP elimination process. RESULTS: There were no significant differences between curves acquired with 1.4 s ISI and any other ISI. Low frequency rTMS did not significantly depress MEP amplitude (P = 0.87). On average, 61 ± 18 (FDI), 60 ± 16 (ADM) and 59 ± 16 (BB) MEPs were needed to construct a representative SR curve. CONCLUSIONS: This study demonstrates that reliable SR curves may be acquired in less than 2 min. At this rate, SR curves become a clinically feasible method for assessing corticospinal excitability in research and rehabilitation settings.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright © 2014 Elsevier Inc. All rights reserved. |
| Uncontrolled Keywords: | corticospinal excitability,rtms,assessment,neuroplasticity |
| Faculty \ School: | Faculty of Medicine and Health Sciences > School of Health Sciences |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Rehabilitation |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 27 Jun 2017 05:06 |
| Last Modified: | 31 Jan 2024 02:15 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/63848 |
| DOI: | 10.1016/j.brs.2013.08.003 |
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