Supramolecular amino acid based hydrogels: probing the contribution of additive molecules using NMR spectroscopy

Ramalhete, Susana, Nartowski, Karol, Sarathchandra, Nichola, Foster, Jamie, Round, Andrew ORCID: https://orcid.org/0000-0001-9026-0620, Angulo, Jesus ORCID: https://orcid.org/0000-0001-7250-5639, Lloyd, Gareth and Khimyak, Yaroslav ORCID: https://orcid.org/0000-0003-0424-4128 (2017) Supramolecular amino acid based hydrogels: probing the contribution of additive molecules using NMR spectroscopy. Chemistry - A European Journal, 23 (33). 8014–8024. ISSN 0947-6539

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Abstract

Supramolecular hydrogels are composed of self-assembled solid networks that restrict the flow of water. L-phenylalanine is the smallest molecule reported to date to form gel networks in water, and it is of particular interest due to its crystalline gel state. Single and multi-component hydrogels of L-phenylalanine are used herein as model materials to develop an NMR-based analytical approach to gain insight into the mechanisms of supramolecular gelation. Structure and composition of the gel fibres were probed using PXRD, solid-state NMR experiments and microscopic techniques. Solution-state NMR studies probed the properties of free gelator molecules in an equilibrium with bound molecules. The dynamics of exchange at the gel/solution interfaces was investigated further using HR-MAS and saturation transfer difference (STD) NMR experiments. This approach allowed us to identify which additive molecules contributed in modifying the material properties.

Item Type:	Article
Additional Information:	Published in Special Issue: 750th issue
Faculty \ School:	Faculty of Science > School of Pharmacy
Depositing User:	Pure Connector
Date Deposited:	21 Apr 2017 05:09
Last Modified:	22 Oct 2022 02:33
URI:	https://ueaeprints.uea.ac.uk/id/eprint/63267
DOI:	10.1002/chem.201700793

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