Supramolecular amino acid based hydrogels: Probing the contribution of additive molecules using NMR spectroscopy

Ramalhete, Susana M., Nartowski, Karol P., Sarathchandra, Nichola, Foster, Jamie S., Round, Andrew N., Angulo, Jesus, Lloyd, Gareth O. and Khimyak, Yaroslav Z. (2017) Supramolecular amino acid based hydrogels: Probing the contribution of additive molecules using NMR spectroscopy. Chemistry - A European Journal, 23 (33). 8014–8024. ISSN 0947-6539

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Abstract

Supramolecular hydrogels are composed of self-assembled solid networks that restrict the flow of water. L-phenylalanine is the smallest molecule reported to date to form gel networks in water, and it is of particular interest due to its crystalline gel state. Single and multi-component hydrogels of L-phenylalanine are used herein as model materials to develop an NMR-based analytical approach to gain insight into the mechanisms of supramolecular gelation. Structure and composition of the gel fibres were probed using PXRD, solid-state NMR experiments and microscopic techniques. Solution-state NMR studies probed the properties of free gelator molecules in an equilibrium with bound molecules. The dynamics of exchange at the gel/solution interfaces was investigated further using HR-MAS and saturation transfer difference (STD) NMR experiments. This approach allowed us to identify which additive molecules contributed in modifying the material properties.

Item Type:	Article
Additional Information:	Published in Special Issue: 750th issue. Funding information: University of East Anglia. Grant Number: PhD Studentship; Engineering and Physical Sciences Research Council. Grant Numbers: Directed Assembly Pump Priming Grant, Directed Assembly Pump-Priming Grant; Heriot-Watt University. Grant Number: PhD studentship; Royal Scociety of Edinburgh/Scottish Government. Grant Number: Personal Research Fellowship
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
Depositing User:	Pure Connector
Date Deposited:	21 Apr 2017 05:09
Last Modified:	10 Apr 2025 00:14
URI:	https://ueaeprints.uea.ac.uk/id/eprint/63267
DOI:	10.1002/chem.201700793

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