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Ramalhete, Susana M., Nartowski, Karol P., Sarathchandra, Nichola, Foster, Jamie S., Round, Andrew N. 
ORCID: https://orcid.org/0000-0001-9026-0620, Angulo, Jesus ORCID: https://orcid.org/0000-0001-7250-5639, Lloyd, Gareth O. and Khimyak, Yaroslav Z. ORCID: https://orcid.org/0000-0003-0424-4128
(2017)
Supramolecular amino acid based hydrogels: Probing the contribution of additive molecules using NMR spectroscopy.
Chemistry - A European Journal, 23 (33).
8014–8024.
ISSN 0947-6539
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Abstract
Supramolecular hydrogels are composed of self-assembled solid networks that restrict the flow of water. L-phenylalanine is the smallest molecule reported to date to form gel networks in water, and it is of particular interest due to its crystalline gel state. Single and multi-component hydrogels of L-phenylalanine are used herein as model materials to develop an NMR-based analytical approach to gain insight into the mechanisms of supramolecular gelation. Structure and composition of the gel fibres were probed using PXRD, solid-state NMR experiments and microscopic techniques. Solution-state NMR studies probed the properties of free gelator molecules in an equilibrium with bound molecules. The dynamics of exchange at the gel/solution interfaces was investigated further using HR-MAS and saturation transfer difference (STD) NMR experiments. This approach allowed us to identify which additive molecules contributed in modifying the material properties.
| Item Type: | Article |
|---|---|
| Additional Information: | Published in Special Issue: 750th issue. Funding information: University of East Anglia. Grant Number: PhD Studentship; Engineering and Physical Sciences Research Council. Grant Numbers: Directed Assembly Pump Priming Grant, Directed Assembly Pump-Priming Grant; Heriot-Watt University. Grant Number: PhD studentship; Royal Scociety of Edinburgh/Scottish Government. Grant Number: Personal Research Fellowship |
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
| UEA Research Groups: | Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter |
| Depositing User: | Pure Connector |
| Date Deposited: | 21 Apr 2017 05:09 |
| Last Modified: | 25 Oct 2024 23:45 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/63267 |
| DOI: | 10.1002/chem.201700793 |
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