Discovery and synthesis of Boletopsins 13 and 14, brominated fungal metabolites of terrestrial origin

Tools

Beekman, Andrew M. ORCID: https://orcid.org/0000-0002-3056-6406, Wossa, Stewart W., Kevo, Oromo, Ma, Paul and Barrow, Russell A. (2015) Discovery and synthesis of Boletopsins 13 and 14, brominated fungal metabolites of terrestrial origin. Journal of Natural Products, 78 (8). pp. 2133-2135. ISSN 0163-3864

Full text not available from this repository.

Abstract

Here we report the discovery and synthesis of complex polybrominated p-terphenyl ethers isolated from a mushroom (Boletopsis sp.) used as a traditional medicine by the Kiovi people in the highlands of Papua New Guinea. Boletopsins 13 and 14 represent the first report of polybrominated fungal metabolites to be produced by a terrestrial fungus. The synthetic method employs 2,4,4,6-tetrabromo-2,5-cyclohexadienone to achieve selective polybromination of the extended aromatic system in a selective and sequential manner.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Related URLs:	https://openresearch-repository.anu.edu....
Depositing User:	Pure Connector
Date Deposited:	16 Mar 2017 01:35
Last Modified:	25 Sep 2024 12:33
URI:	https://ueaeprints.uea.ac.uk/id/eprint/62976
DOI:	10.1021/acs.jnatprod.5b00202

Actions (login required)

View Item