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Levell, Nick J. 
ORCID: https://orcid.org/0000-0003-3393-8305, Shuster, Sam, Munro, Colin S. and Friedmann, Peter S.
(1995)
Remission of ordinary psoriasis following a short clearance course of cyclosporin.
Acta Dermato-Venereologica, 75 (1).
pp. 65-69.
ISSN 0001-5555
Abstract
We set out to show that the assumption is incorrect that continuous treatment with cyclosporin is necessary in psoriasis, as this tenet forms a basis for current recommended treatment regimens. Sixty patients with mild to moderate plaque psoriasis were allocated at random to treatment with oral cyclosporin 5 mg/kg/day (30 patients) or topical dithranol and ultraviolet B therapy (30 patients) for up to 16 weeks until clear (median time 6 weeks cyclosporin and 8 dithranol), and the times to relapse compared. The patients were seen monthly for up to 8 months, and the severity and the extent of psoriasis were assessed. Relapse, defined as return of psoriasis to 50% of the area at the start of the trial or patient demand for further treatment, was not significantly different between the groups (hazard ratio 1.11, 95% CI 0.55-2.32). No patients suffered a rebound of severe disease and none relapsed in the first 8 weeks after stopping treatment. The relapse rate was higher following cyclosporin from 8 to 28 weeks after treatment and following dithranol from 28 to 34 weeks. The patients with arthritis had a higher median joint severity score at relapse than prior to treatment with cyclosporin. At the end of 8 months, 5 patients treated with dithranol and 8 patients with cyclosporin remained clear, 75% and 67% having relapsed. We conclude that rapid relapse does not occur after clearance of mild to moderate plaque psoriasis with cyclosporin and the relapse rate was no different from dithranol treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | relapse,dithranol,plaques,joints,nails,low-dose cyclosporin |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 14 Feb 2017 02:23 |
| Last Modified: | 22 Oct 2022 02:18 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/62509 |
| DOI: | 10.2340/00015555756569 |
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