Pyoderma gangrenosum in association with Janus kinase 2 (JAK2V617F) mutation

Palanivel, J A, Macbeth, A E and Levell, N J (2013) Pyoderma gangrenosum in association with Janus kinase 2 (JAK2V617F) mutation. Clinical and Experimental Dermatology, 38 (1). pp. 44-46. ISSN 0307-6938

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Abstract

Pyoderma gangrenosum (PG) commonly occurs in association with various haematological and inflammatory disorders. We report a new association, a Janus kinase (JAK)2 mutation, in a 63-year-old patient with PG. We hypothesise that PG occurs by direct activation of JAK along with signal transducers and activators of transcription (STAT), a common mechanism involved in the pathogenesis of inflammatory and haematological diseases.

Item Type: Article
Additional Information: © The Author(s). CED © 2012 British Association of Dermatologists.
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 11 Feb 2017 02:18
Last Modified: 10 May 2020 23:49
URI: https://ueaeprints.uea.ac.uk/id/eprint/62450
DOI: 10.1111/j.1365-2230.2012.04375.x

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