Pyoderma gangrenosum in association with Janus kinase 2 (JAK2V617F) mutation

Palanivel, J. A., Macbeth, A. E. and Levell, N. J. ORCID: https://orcid.org/0000-0003-3393-8305 (2013) Pyoderma gangrenosum in association with Janus kinase 2 (JAK2V617F) mutation. Clinical and Experimental Dermatology, 38 (1). pp. 44-46. ISSN 0307-6938

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Abstract

Pyoderma gangrenosum (PG) commonly occurs in association with various haematological and inflammatory disorders. We report a new association, a Janus kinase (JAK)2 mutation, in a 63-year-old patient with PG. We hypothesise that PG occurs by direct activation of JAK along with signal transducers and activators of transcription (STAT), a common mechanism involved in the pathogenesis of inflammatory and haematological diseases.

Item Type:	Article
Additional Information:	© The Author(s). CED © 2012 British Association of Dermatologists.
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	Pure Connector
Date Deposited:	11 Feb 2017 02:18
Last Modified:	25 Sep 2024 12:35
URI:	https://ueaeprints.uea.ac.uk/id/eprint/62450
DOI:	10.1111/j.1365-2230.2012.04375.x

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