Biomarkers in adult asthma: a systematic review of 8-isoprostane in exhaled breath condensate

Peel, Adam M, Crossman-Barnes, Christina-Jane, Tang, Jonathan ORCID:, Fowler, Stephen, Davies, Gwyneth, Wilson, Andrew and Loke, Yoon (2017) Biomarkers in adult asthma: a systematic review of 8-isoprostane in exhaled breath condensate. Journal of Breath Research, 11 (1). ISSN 1752-7155

[thumbnail of Accepted manuscript]
PDF (Accepted manuscript) - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (607kB) | Preview


Objectives: We aimed to assess the evidence for the use of 8-isoprostane in exhaled breath condensate (EBC) as a biomarker in adult asthma. Design: A systematic review and meta-analysis of EBC 8-isoprostane. Methods: We searched a number of online databases (including PubMed, Embase and Scopus) in January 2016. We included studies of adult non-smokers with EBC collection and asthma diagnosis conducted according to recognised guidelines. We aimed to pool data using random effects meta-analysis and assess heterogeneity using I2. Results: We included twenty studies, the findings from which were inconsistent. Seven studies (n = 329) reported 8-isoprostane levels in asthma to be significantly higher than that of control groups, whilst six studies (n = 403) did not. Only four studies were appropriate for inclusion in a random effects meta-analysis of mean difference. This found a statistically significant between-groups difference of 22pg/ml. Confidence in the result is limited by the small number of studies and by substantial statistical heterogeneity (I2 = 94). Conclusion: The clinical value of EBC 8-isoprostane as a quantitative assessment of oxidative stress in asthma remains unclear due to variability in results and methodological heterogeneity. It is essential to develop a robust and standardised methodology if the use of EBC 8-isoprostane in asthma is to be properly evaluated.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: Pure Connector
Date Deposited: 02 Feb 2017 03:50
Last Modified: 19 May 2023 00:30
DOI: 10.1088/1752-7163/aa5a8a

Actions (login required)

View Item View Item