Tools
Tools
Peel, Adam M, Crossman-Barnes, Christina-Jane, Tang, Jonathan 
ORCID: https://orcid.org/0000-0001-6305-6333, Fowler, Stephen, Davies, Gwyneth, Wilson, Andrew and Loke, Yoon
(2017)
Biomarkers in adult asthma: a systematic review of 8-isoprostane in exhaled breath condensate.
Journal of Breath Research, 11 (1).
ISSN 1752-7155
Preview |
PDF (Accepted manuscript)
- Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (607kB) | Preview |
Abstract
Objectives: We aimed to assess the evidence for the use of 8-isoprostane in exhaled breath condensate (EBC) as a biomarker in adult asthma. Design: A systematic review and meta-analysis of EBC 8-isoprostane. Methods: We searched a number of online databases (including PubMed, Embase and Scopus) in January 2016. We included studies of adult non-smokers with EBC collection and asthma diagnosis conducted according to recognised guidelines. We aimed to pool data using random effects meta-analysis and assess heterogeneity using I2. Results: We included twenty studies, the findings from which were inconsistent. Seven studies (n = 329) reported 8-isoprostane levels in asthma to be significantly higher than that of control groups, whilst six studies (n = 403) did not. Only four studies were appropriate for inclusion in a random effects meta-analysis of mean difference. This found a statistically significant between-groups difference of 22pg/ml. Confidence in the result is limited by the small number of studies and by substantial statistical heterogeneity (I2 = 94). Conclusion: The clinical value of EBC 8-isoprostane as a quantitative assessment of oxidative stress in asthma remains unclear due to variability in results and methodological heterogeneity. It is essential to develop a robust and standardised methodology if the use of EBC 8-isoprostane in asthma is to be properly evaluated.
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |