The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling

Stegmann, Martin, Monaghan, Jacqueline, Smakowska-Luzan, Elwira, Rovenich, Hanna, Lehner, Anita, Holton, Nicholas, Belkhadir, Youssef and Zipfel, Cyril (2017) The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling. Science, 355 (6322). pp. 287-289. ISSN 0036-8075

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Abstract

In plants, perception of invading pathogens involves cell-surface immune receptor kinases. Here, we report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plant immunity. This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex formation of the immune receptor kinases EF-TU RECEPTOR (EFR) and FLAGELLIN-SENSING 2 (FLS2) with their co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) to initiate immune signaling. We show that FER acts as a RALF-regulated scaffold modulating receptor kinase complex assembly. A similar scaffolding mechanism may underlie RALF function in other signalling pathways.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Biological Sciences Faculty of Science > The Sainsbury Laboratory
UEA Research Groups:	Faculty of Science > Research Groups > Plant Sciences
Depositing User:	Pure Connector
Date Deposited:	17 Dec 2016 00:08
Last Modified:	21 Oct 2022 08:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/61765
DOI:	10.1126/science.aal2541

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