Tools
ToolsLázár, Alpár S, Slak, Ana, Lo, June Chi-Yan, Santhi, Nayantara, von Schantz, Malcolm, Archer, Simon N, Groeger, John A and Dijk, Derk-Jan (2012) Sleep, diurnal preference, health, and psychological well-being:A prospective single-allelic-variation study. Chronobiology International, 29 (2). pp. 131-146. ISSN 0742-0528
Full text not available from this repository. (Request a copy)Abstract
Individual differences in sleep and diurnal preference associate with physical and mental health characteristics, but few genetic determinants of these differences have been identified. A variable number tandem repeat (VNTR) polymorphism in the PERIOD3 (PER3) gene (rs57875989) has been reported to associate with diurnal preference, i.e., preferred timing of waking and sleep. Here, the authors investigate in a prospective single-candidate genetic variant study whether allelic variation for this polymorphism associates also with reported actual sleep timing and sleep duration, as well as psychological and health measures. Six hundred and seventy-five subjects, aged 20 to 35 yrs, completed questionnaires to assess sleep and psychological and health characteristics and were genotyped for the PER3 VNTR. Homozygosity for the longer allele (PER3(5/5)) of the VNTR was associated with increased morning preference, earlier wake time and bedtime, and reduced daytime sleepiness. Separate analyses of work and rest days demonstrated that the increase in time in bed during rest days was greatest in PER3(5/5) homozygotes. PER3 genotype modified the effects of sleep timing and duration on fluid intelligence and body mass index. Genotype was not associated with physical or psychological characteristics as assessed by the SF-36 Health Questionnaire, the General Health Questionnaire, the Big Five Inventory, the Behavioral Inhibition System-Behavioral Activation System scales, and the Positive and Negative Affect Scale, even though these measures varied significantly with diurnal preference as assessed by the Morningness-Eveningness Questionnaire. Whereas diurnal preference also predicts mental health and psychological characteristics, as well as sleep timing, the PER3 VNTR specifically affects measures of sleep timing and may also modify the effects of sleep on health outcome measures.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | adult,affect,alleles,circadian rhythm,female,genotype,humans,male,mental health,minisatellite repeats,period circadian proteins,polymorphism, genetic,prospective studies,sleep,surveys and questionnaires,wakefulness,young adult,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > School of Health Sciences |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health |
| Depositing User: | Pure Connector |
| Date Deposited: | 07 Dec 2016 00:07 |
| Last Modified: | 19 Oct 2023 01:52 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/61615 |
| DOI: | 10.3109/07420528.2011.641193 |
Actions (login required)
 |
View Item |