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Lehman, Margot, Gorayski, Peter, Watson, Susanne, Edeling, Desiree, Jackson, James and Whitty, Jennifer 
ORCID: https://orcid.org/0000-0002-5886-1933
(2016)
Patient preferences regarding prophylactic cranial irradiation: A discrete choice experiment.
Radiotherapy and Oncology, 121 (2).
225–231.
ISSN 0167-8140
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Abstract
Introduction: In patients with non-small cell lung cancer (NSCLC) treated with chemoradiotherapy (CRT), prophylactic cranial irradiation (PCI) is not standard practice. This study determined patient preferences for PCI with respect to survival benefit, reduction in brain metastases (BM) and acceptable toxicity. Methods: A Discrete Choice Experiment was completed pre- and post-treatment. Patients made 15 hypothetical choices between two alternative PCI treatments described by four attributes: amount of life gained, chance of BM, ability to care for oneself, and loss of memory. Participants also chose between PCI and no PCI. Results: 54 and 46 surveys were completed pre- and post-treatment. The most important attributes pre-treatment were: a survival benefit >6 months, of 3–6 months, avoiding severe problems with memory and self-care, avoiding quite a bit of difficulty with memory and maximally reducing BM recurrence. Post-treatment, BM reduction became more important. 90% of patients would accept PCI for a survival benefit >6 months, with a maximal reduction in BM even if severe memory/self-care problems occurred. With a 10% reduction in BM and mild problems with memory and self-care 70% of patients pre- (90% post-treatment) would accept PCI for a survival benefit of 1–3 months, and 52% pre- (78% post-treatment) for no survival benefit. Conclusion: Improvement in survival is the most important attribute of PCI with patients willing to accept significant toxicity for maximum survival and less toxicity for less survival benefit. BM reduction became more important after treatment. The majority of patients would accept PCI for no survival benefit and a reduction in BM.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | lung cancer,prophylactic cranial irradiation,patient preferences,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Health Economics Faculty of Medicine and Health Sciences > Research Groups > Respiratory and Airways Group Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 16 Nov 2016 12:00 |
| Last Modified: | 22 Oct 2022 01:33 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/61375 |
| DOI: | 10.1016/j.radonc.2016.09.003 |
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