A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS

Schwarz, Konstantin, Singh, Satnam, Parasuraman, Satish Kumar, Bruce, Maggie, Shepstone, Lee, Feelisch, Martin, Minnion, Magdalena, Ahmad, Shakil, Horowitz, John, Dawson, Dana K and Frenneaux, Michael P (2016) A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS. Future Cardiology, 12 (6). pp. 617-626. ISSN 1479-6678

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Abstract

In an aging western population, a significant number of patients continue to suffer from angina once all revascularization and optimal medical treatment options are exhausted. Under experimental conditions, oral supplementation with inorganic nitrate was shown to exhibit a blood pressure-lowering effect, and has also been shown to promote angiogenesis, improve endothelial dysfunction and mitochondrial efficiency in skeletal muscle. It is unknown whether similar changes occur in cardiac muscle. In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 08 Nov 2016 17:00
Last Modified: 18 Sep 2020 00:10
URI: https://ueaeprints.uea.ac.uk/id/eprint/61275
DOI: 10.2217/fca-2016-0026

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