A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS

Schwarz, Konstantin, Singh, Satnam, Parasuraman, Satish Kumar, Bruce, Maggie, Shepstone, Lee, Feelisch, Martin, Minnion, Magdalena, Ahmad, Shakil, Horowitz, John, Dawson, Dana K and Frenneaux, Michael P (2016) A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS. Future Cardiology, 12 (6). pp. 617-626. ISSN 1479-6678

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Abstract

In an aging western population, a significant number of patients continue to suffer from angina once all revascularization and optimal medical treatment options are exhausted. Under experimental conditions, oral supplementation with inorganic nitrate was shown to exhibit a blood pressure-lowering effect, and has also been shown to promote angiogenesis, improve endothelial dysfunction and mitochondrial efficiency in skeletal muscle. It is unknown whether similar changes occur in cardiac muscle. In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Population Health
Related URLs:	http://www.futuremedicine.com/doi/10.221...
Depositing User:	Pure Connector
Date Deposited:	08 Nov 2016 17:00
Last Modified:	28 Oct 2023 01:05
URI:	https://ueaeprints.uea.ac.uk/id/eprint/61275
DOI:	10.2217/fca-2016-0026

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