Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA

Waller, Zoë A. E., Pinchbeck, Benjamin J., Buguth, Bhovina Seewoodharry, Meadows, Timothy G., Richardson, David J. and Gates, Andrew J. (2016) Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA. Chemical Communications, 52 (92). pp. 13511-13514. ISSN 1359-7345

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Abstract

Here we present a chemical-biology study in the model soil bacterium Paracoccus denitrificans, where we show ligand-specific control of nitrate assimilation. Stabilization of a G-quadruplex in the promoter region of the nas genes, encoding the assimilatory nitrate/nitrite reductase system, is achieved using known quadruplex ligands and results in attenuation of gene transcription.

Item Type: Article
Additional Information: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Faculty \ School: Faculty of Science > School of Pharmacy
Faculty of Science > School of Biological Sciences
Depositing User: Pure Connector
Date Deposited: 01 Nov 2016 12:00
Last Modified: 28 Jul 2020 23:39
URI: https://ueaeprints.uea.ac.uk/id/eprint/61193
DOI: 10.1039/c6cc06057a

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