Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA

Waller, Zoë A. E., Pinchbeck, Benjamin J., Buguth, Bhovina Seewoodharry, Meadows, Timothy G., Richardson, David J. and Gates, Andrew J. (2016) Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA. Chemical Communications, 52 (92). pp. 13511-13514. ISSN 1359-7345

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Abstract

Here we present a chemical-biology study in the model soil bacterium Paracoccus denitrificans, where we show ligand-specific control of nitrate assimilation. Stabilization of a G-quadruplex in the promoter region of the nas genes, encoding the assimilatory nitrate/nitrite reductase system, is achieved using known quadruplex ligands and results in attenuation of gene transcription.

Item Type:	Article
Additional Information:	This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024) Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Molecular Microbiology Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry Faculty of Science > Research Groups > Organisms and the Environment Faculty of Science > Research Groups > Wolfson Centre for Advanced Environmental Microbiology
Depositing User:	Pure Connector
Date Deposited:	01 Nov 2016 12:00
Last Modified:	19 May 2025 08:35
URI:	https://ueaeprints.uea.ac.uk/id/eprint/61193
DOI:	10.1039/c6cc06057a

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