Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA
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Waller, Zoë A. E., Pinchbeck, Benjamin J., Buguth, Bhovina Seewoodharry, Meadows, Timothy G., Richardson, David J. and Gates, Andrew J. (2016) Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA. Chemical Communications, 52 (92). pp. 13511-13514. ISSN 1359-7345
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Abstract
Here we present a chemical-biology study in the model soil bacterium Paracoccus denitrificans, where we show ligand-specific control of nitrate assimilation. Stabilization of a G-quadruplex in the promoter region of the nas genes, encoding the assimilatory nitrate/nitrite reductase system, is achieved using known quadruplex ligands and results in attenuation of gene transcription.
Item Type: | Article |
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Additional Information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
Faculty \ School: | Faculty of Science > School of Pharmacy Faculty of Science > School of Biological Sciences |
Depositing User: | Pure Connector |
Date Deposited: | 01 Nov 2016 12:00 |
Last Modified: | 05 Nov 2020 00:48 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/61193 |
DOI: | 10.1039/c6cc06057a |
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