Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA

Waller, Zoë A. E., Pinchbeck, Benjamin J., Buguth, Bhovina Seewoodharry, Meadows, Timothy G., Richardson, David J. ORCID: https://orcid.org/0000-0002-6847-1832 and Gates, Andrew J. ORCID: https://orcid.org/0000-0002-4594-5038 (2016) Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA. Chemical Communications, 52 (92). pp. 13511-13514. ISSN 1359-7345

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Abstract

Here we present a chemical-biology study in the model soil bacterium Paracoccus denitrificans, where we show ligand-specific control of nitrate assimilation. Stabilization of a G-quadruplex in the promoter region of the nas genes, encoding the assimilatory nitrate/nitrite reductase system, is achieved using known quadruplex ligands and results in attenuation of gene transcription.

Item Type: Article
Additional Information: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Faculty \ School: Faculty of Science > School of Pharmacy
Faculty of Science > School of Biological Sciences
Depositing User: Pure Connector
Date Deposited: 01 Nov 2016 12:00
Last Modified: 24 Sep 2022 01:42
URI: https://ueaeprints.uea.ac.uk/id/eprint/61193
DOI: 10.1039/c6cc06057a

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