Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA

Waller, Zoë A. E., Pinchbeck, Benjamin J., Buguth, Bhovina Seewoodharry, Meadows, Timothy G., Richardson, David J. ORCID: https://orcid.org/0000-0002-6847-1832 and Gates, Andrew J. ORCID: https://orcid.org/0000-0002-4594-5038 (2016) Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA. Chemical Communications, 52 (92). pp. 13511-13514. ISSN 1359-7345

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Abstract

Here we present a chemical-biology study in the model soil bacterium Paracoccus denitrificans, where we show ligand-specific control of nitrate assimilation. Stabilization of a G-quadruplex in the promoter region of the nas genes, encoding the assimilatory nitrate/nitrite reductase system, is achieved using known quadruplex ligands and results in attenuation of gene transcription.

Item Type:	Article
Additional Information:	This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024) Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Molecular Microbiology Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry Faculty of Science > Research Groups > Organisms and the Environment
Depositing User:	Pure Connector
Date Deposited:	01 Nov 2016 12:00
Last Modified:	18 Oct 2024 23:44
URI:	https://ueaeprints.uea.ac.uk/id/eprint/61193
DOI:	10.1039/c6cc06057a

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