Substance use, medication adherence and outcome one year following a first episode of psychosis

Colizzi, Marco, Carra, Elena, Fraietta, Sara, Lally, John, Quattrone, Diego, Bonaccorso, Stefania, Mondelli, Valeria, Ajnakina, Olesya, Dazzan, Paola, Trotta, Antonella, Sideli, Lucia, Kolliakou, Anna, Gaughran, Fiona, Khondoker, Mizanur ORCID: https://orcid.org/0000-0002-1801-1635, David, Anthony S., Murray, Robin M., MacCabe, James H. and Di Forti, Marta (2016) Substance use, medication adherence and outcome one year following a first episode of psychosis. Schizophrenia Research, 170 (2-3). pp. 311-317. ISSN 0920-9964

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Abstract

Both substance use and poor medication adherence are associated with poor outcome in psychosis. To clarify the contributions of substance use and poor medication adherence to poor outcome in the year following a first episode of psychosis, 205 patients were evaluated for use of tobacco, alcohol, cannabis and stimulants at their psychosis onset, and in a 1-year follow-up. Data on medication adherence and symptom remission were also collected. Patients had high rates of overall substance use before (37-65%) and after psychosis onset (45-66%). 44% showed poor medication adherence and 55% did not reach remission from psychosis. Nicotine dependence and cannabis use after psychosis onset significantly predicted both poor medication adherence and non remission, and poor medication adherence mediated the effects of these substances on non-remission. In conclusion, medication adherence lies on the causal pathway between nicotine dependence and cannabis on the one hand and non-remission on the other. (C) 2015 Elsevier B.V. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	first episode psychosis,substance use,cannabis use,nicotine dependence,medication adherence,remission
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Population Health
Depositing User:	Pure Connector
Date Deposited:	24 Sep 2016 00:24
Last Modified:	19 Oct 2023 01:45
URI:	https://ueaeprints.uea.ac.uk/id/eprint/60032
DOI:	10.1016/j.schres.2015.11.016

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