Dissemination of multiple carbapenem-resistant clones of Acinetobacter baumannii in the Eastern District of Saudi Arabia

Al-Sultan, Abdulrahman A., Evans, Benjamin A. ORCID: https://orcid.org/0000-0001-6849-9758, Aboulmagd, Elsayed, Al-Qahtani, Ahmed A., Bohol, Marie Fe F., Al-Ahdal, Mohammed N., Opazo, Andres F. and Amyes, Sebastian G. B. (2015) Dissemination of multiple carbapenem-resistant clones of Acinetobacter baumannii in the Eastern District of Saudi Arabia. Frontiers in Microbiology, 6. ISSN 1664-302X

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Abstract

It has previously been shown that carbapenem-resistant Acinetobacter baumannii are frequently detected in Saudi Arabia. The present study aimed to identify the epidemiology and distribution of antibiotic resistance determinants in these bacteria. A total of 83 A. baumannii isolates were typed by pulsed-field gel electrophoresis (PFGE), and screened by PCR for carbapenemase genes and insertion sequences. Antibiotic sensitivity to imipenem, meropenem, tigecycline, and colistin were determined. Eight different PFGE groups were identified, and were spread across multiple hospitals. Many of the PFGE groups contained isolates belonging to World-wide clone 2. Carbapenem resistance or intermediate resistance was detected in 69% of isolates. The bla VIM gene was detected in 94% of isolates, while bla OXA-23-like genes were detected in 58%. The data demonstrate the co-existence and wide distribution of a number of clones of carbapenem-resistant A. baumannii carrying multiple carbapenem-resistance determinants within hospitals in the Eastern Region of Saudi Arabia.

Item Type:	Article
Additional Information:	Copyright © 2015 Al-Sultan, Evans, Aboulmagd, Al-Qahtani, Bohol, Al-Ahdal, Opazo and Amyes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Uncontrolled Keywords:	acinetobacter baumannii,carbapenem resistance,saudi arabia,pfge,oxa,vim
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Pathogen Biology Group
Depositing User:	Pure Connector
Date Deposited:	24 Sep 2016 00:09
Last Modified:	25 Sep 2024 12:07
URI:	https://ueaeprints.uea.ac.uk/id/eprint/59876
DOI:	10.3389/fmicb.2015.00634

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