Report from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)

Chalmers, J.R., Simpson, E., Apfelbacher, C.J., Thomas, K.S., von Kobyletzki, L., Schmitt, J., Singh, J.A., Svensson, Å., Williams, H.C., Abuabara, K., Aoki, V., Ardeleanu, M., Awici-Rasmussen, M., Barbarot, S., Berents, T.L., Block, J., Bragg, A., Burton, T., Bjerring Clemmensen, K.K., Creswell-Melville, A., Dinesen, M., Drucker, A., Eckert, L., Flohr, C., Garg, M., Gerbens, L.A.A., Graff, A.L.B., Hanifin, J., Heinl, D., Humphreys, R., Ishii, H.A., Kataoka, Y., Leshem, Y.A., Marquort, B., Massuel, M.-A., Merhand, S., Mizutani, H., Murota, H., Murrell, D.F., Nakahara, T., Nasr, I., Nograles, K., Ohya, Y., Osterloh, I., Pander, J., Prinsen, C., Purkins, L., Ridd, M., Sach, T. ORCID: https://orcid.org/0000-0002-8098-9220, Schuttelaar, M.-L. A., Shindo, S., Smirnova, J., Sulzer, A., Synnøve Gjerde, E., Takaoka, R., Vestby Talmo, H., Tauber, M., Torchet, F., Volke, A., Wahlgren, C.-F., Weidinger, S., Weisshaar, E., Wollenberg, A., Yamaga, K., Zhao, C.Y. and Spuls, P.I. (2016) Report from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative). British Journal of Dermatology, 175 (1). 69–79. ISSN 0007-0963

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Abstract

This article is a report of the fourth meeting of the Harmonising Outcome Measures for Eczema (HOME) initiative held in Malmö, Sweden on 23–24 April 2015 (HOME IV). The aim of the meeting was to achieve consensus over the preferred outcome instruments for measuring patient-reported symptoms and quality of life for the HOME core outcome set for atopic eczema (AE). Following presentations, which included data from systematic reviews, consensus discussions were held in a mixture of whole group and small group discussions. Small groups were allocated a priori to ensure representation of different stakeholders and countries. Decisions were voted on using electronic keypads. For the patient-reported symptoms, the group agreed by vote that itch, sleep loss, dryness, redness/inflamed skin and irritated skin were all considered essential aspects of AE symptoms. Many instruments for capturing patient-reported symptoms were discussed [including the Patient-Oriented SCOring Atopic Dermatitis index, Patient-Oriented Eczema Measure (POEM), Self-Administered Eczema Area and Severity Index, Itch Severity Scale, Atopic Dermatitis Quickscore and the Nottingham Eczema Severity Score] and, by consensus, POEM was selected as the preferred instrument to measure patient-reported symptoms. Further work is needed to determine the reliability and measurement error of POEM. Further work is also required to establish the importance of pain/soreness and the importance of collecting information regarding the intensity of symptoms in addition to their frequency. Much of the discussion on quality of life concerned the Dermatology Life Quality Index and Quality of Life Index for Atopic Dermatitis; however, consensus on a preferred instrument for measuring this domain could not be reached. In summary, POEM is recommended as the HOME core outcome instrument for measuring AE symptoms.

Item Type:	Article
Additional Information:	© 2016 The Authors. British Journal of Dermatology This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use,distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Health Economics Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	Pure Connector
Date Deposited:	24 Sep 2016 00:08
Last Modified:	25 Oct 2022 08:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/59847
DOI:	10.1111/bjd.14773

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