Tools
Tools
Grundmann, Hajo, Glasner, Corinna, Albiger, Barbara, Aanensen, David M., Tomlinson, Chris T., Andrasević, Arjana Tambić, Cantón, Rafael, Carmeli, Yehuda, Friedrich, Alexander W., Giske, Christian G., Glupczynski, Youri, Gniadkowski, Marek, Livermore, David M. 
ORCID: https://orcid.org/0000-0002-9856-3703, Nordmann, Patrice, Poirel, Laurent, Rossolini, Gian M., Seifert, Harald, Vatopoulos, Alkiviadis, Walsh, Timothy, Woodford, Neil and Monnet, Dominique L.
and
European Survey on Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) Working Group
(2017)
Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational study.
The Lancet Infectious Diseases, 17 (2).
153–163.
ISSN 1473-3099
![[thumbnail of Figure 1]](https://ueaeprints.uea.ac.uk/style/images/fileicons/application_pdf.png) |
PDF (Figure 1)
- Accepted Version
Restricted to Repository staff only until 31 December 2099. Request a copy |
|
PDF (Table 5)
- Accepted Version
Restricted to Repository staff only until 31 December 2099. Request a copy |
Preview |
PDF (Table 2)
- Accepted Version
Download (18kB) | Preview |
Preview |
PDF (Manuscript)
- Accepted Version
Download (710kB) | Preview |
Preview |
PDF (Table 1)
- Accepted Version
Download (78kB) | Preview |
|
PDF (Table 3b_Eco)
- Accepted Version
Restricted to Repository staff only until 31 December 2099. Request a copy |
|
PDF (Table 4)
- Accepted Version
Restricted to Repository staff only until 31 December 2099. Request a copy |
|
PDF (Table 3a_Kpn)
- Accepted Version
Restricted to Repository staff only until 31 December 2099. Request a copy |
Preview |
PDF (Accepted manuscript)
- Accepted Version
Download (710kB) | Preview |
Abstract
Background: Gaps in the diagnostic capacity and heterogeneity of national surveillance and reporting standards in Europe make it difficult to contain carbapenemase-producing Enterobacteriaceae. We report the development of a consistent sampling framework and the results of the first structured survey on the occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in European hospitals. Methods: National expert laboratories recruited hospitals with diagnostic capacities, who collected the first ten carbapenem non-susceptible clinical isolates of K pneumoniae or E coli and ten susceptible same-species comparator isolates and pertinent patient and hospital information. Isolates and data were relayed back to national expert laboratories, which made laboratory-substantiated information available for central analysis. Findings: Between Nov 1, 2013, and April 30, 2014, 455 sentinel hospitals in 36 countries submitted 2703 clinical isolates (2301 [85%] K pneumoniae and 402 (15%) E coli). 850 (37%) of 2301 K pneumoniae samples and 77 (19%) of 402 E coli samples were carbapenemase (KPC, NDM, OXA-48-like, or VIM) producers. The ratio of K pneumoniae to E coli was 11:1. 1·3 patients per 10 000 hospital admissions had positive clinical specimens. Prevalence differed greatly, with the highest rates in Mediterranean and Balkan countries. Carbapenemase-producing K pneumoniae isolates showed high resistance to last-line antibiotics. Interpretation: This initiative shows an encouraging commitment by all participants, and suggests that challenges in the establishment of a continent-wide enhanced sentinel surveillance for carbapenemase-producing Enterobacteriaeceae can be overcome. Strengthening infection control efforts in hospitals is crucial for controlling spread through local and national health care networks.
| Item Type: | Article |
|---|---|
| Additional Information: | Title changed post-acceptance. |
| Uncontrolled Keywords: | carbapenemase,klebsiella pneumoniae,escherichia coli,epidemiology,europe,surveillance,public health,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 24 Sep 2016 00:05 |
| Last Modified: | 03 Nov 2022 15:40 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/59805 |
| DOI: | 10.1016/S1473-3099(16)30257-2 |
Actions (login required)
 |
View Item |