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Bulman Page, Philip C., Stephenson, G. Richard 
ORCID: https://orcid.org/0000-0003-1487-9178, Harvey, James and Slawin, Alexandra M. Z.
(2016)
Ruthenium-free preparation of 1,5-disubstituted triazoles by alkylative debenzylation of 1,4-disubstituted triazoles.
Synlett, 27 (17).
pp. 2500-2504.
ISSN 0936-5214
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Abstract
A method that cleanly converts the 1,4-disubstituted 1,2,3-triazole products of the copper-catalyzed ‘click’ dipolar cycloaddition reaction of benzyl azide with terminal alkynes into 1,5-disubstituted triazoles is described. Selective N-alkylation of 1,4-disubstituted 1,2,3-triazoles under microwave irradiation is followed by debenzylation of the resulting 1,3,4-trisubstituted triazolium cations by treatment with potassium tert-butoxide.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 1,2,3-triazole,debenzylation,microwave,disubstituted,rearrangement |
| Faculty \ School: | Faculty of Science > School of Chemistry (former - to 2024) |
| UEA Research Groups: | Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemistry of Materials and Catalysis |
| Depositing User: | Pure Connector |
| Date Deposited: | 23 Sep 2016 23:59 |
| Last Modified: | 25 Sep 2024 12:05 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/59760 |
| DOI: | 10.1055/s-0035-1562603 |
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