The role of metal ions in metal-on-metal total hip replacement

Ebreo, Darren (2016) The role of metal ions in metal-on-metal total hip replacement. Doctoral thesis, University of East Anglia.

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Role of Metal Ions in Metal on Metal Total Hip Replacement
Metal-on-metal (MoM) total hip replacement (THR) offered theoretical advantages of
decreased wear and increased functional outcomes. MoM bearings have been
associated with sterile inflammatory masses and significant soft tissue destruction
with poorer outcomes following revision surgery. The natural history of adverse
reactions to metal debris (ARMD) is unknown, but may represent contributions from
bearing surface wear, taper junction wear, and corrosion. Immunological and genetic
factors may influence susceptibility to development of ARMD.
Between 1997 and 2004, 652 Ultima TPS THRs (DePuy) were implanted in 545
patients who went on to experience a high rate of early implant failure (13.8%).
Management of these patients has evolved beyond regular clinical follow up with plain
radiographs to include surveillance monitoring of trends in levels of blood metal ions
and staging of disease using metal artefact reduction (MAR) MRI.
This study investigated:

Item Type: Thesis (Doctoral)
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Users 7376 not found.
Date Deposited: 15 Jun 2016 11:18
Last Modified: 17 Jun 2016 08:45

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