The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: A randomised controlled trial

Arden, Nigel K., Cro, Suzie, Sheard, Sally, Doré, Caroline J., Bara, Anna, Tebbs, Susan A., Hunter, David J., James, Samuel, Cooper, Cyrus, O'Neill, Terence W., Macgregor, Alexander ORCID: https://orcid.org/0000-0003-2163-2325, Birrell, Fraser and Keen, Richard (2016) The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: A randomised controlled trial. Osteoarthritis and Cartilage, 24 (11). 1858–1866. ISSN 1063-4584

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Abstract

OBJECTIVE: Epidemiological data suggest low serum 25-hydroxyvitamin D3 (25-OH-D3) levels are associated with radiological progression of knee osteoarthritis (OA). This study aimed to assess whether vitamin D supplementation can slow the rate of progression.  METHOD: A 3 year, double-blind, randomised, placebo-controlled trial of 474 patients aged over 50 with radiographically evident knee OA comparing 800 IU cholecalciferol daily with placebo. Primary outcome was difference in rate of medial joint space narrowing (JSN). Secondary outcomes included lateral JSN, Kellgren and Lawrence grade, WOMAC pain, function, stiffness and the Get up and Go test.  RESULTS: Vitamin D supplementation increased 25-OH-D3 from an average of 20·7 (SD 8·9) μg/L to 30·4 (SD 7·7) μg/L, compared to 20·7 (SD 8·1) μg/L and 20·3 (SD 8·1) μg/L in the placebo group. There was no significant difference in the rate of JSN over three years in the medial compartment of the index knee between the treatment group (average -0.01 mm/year) and placebo group (-0.08 mm/year), average difference 0.08 mm/year, (95% CI [-0·14 to 0·29], p=0.49). No significant interaction was found between baseline vitamin D levels and treatment effect. There were no significant differences for any of the secondary outcome measures.  CONCLUSION: Vitamin D supplementation did not slow the rate of JSN or lead to reduced pain, stiffness or functional loss over a three year period. On the basis of these findings we consider that vitamin D supplementation has no role in the management of knee OA.

Item Type:	Article
Additional Information:	Data sharing statement: Anonymised patient level data and statistical code available from the corresponding author. Funding information: Funding was received from Arthritis Research Campaign (now Arthritis Research UK, grant number K0576). Additional support was received from the National Institute for Health Research (NIHR) Musculoskeletal Biomedical Research Unit, University of Oxford (grant number HFRWGQ00 task HF00.EA BRU). Researchers were independent from funders and sponsors. The funder of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report.
Uncontrolled Keywords:	vitamin d,knee,randomised placebo-controlled trial,osteoarthritis
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Depositing User:	Pure Connector
Date Deposited:	14 Jun 2016 15:00
Last Modified:	08 Oct 2024 08:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/59336
DOI:	10.1016/j.joca.2016.05.020

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