Meta-analysis of overnight closed-loop randomized studies in children and adults with type 1 diabetes:the Cambridge cohort

Kumareswaran, Kavita, Elleri, Daniela, Allen, Janet M, Harris, Julie, Xing, Dongyuan, Kollman, Craig, Nodale, Marianna, Murphy, Helen R, Amiel, Stephanie A, Heller, Simon R, Wilinska, Malgorzata E, Acerini, Carlo L, Evans, Mark L, Dunger, David B and Hovorka, Roman (2011) Meta-analysis of overnight closed-loop randomized studies in children and adults with type 1 diabetes:the Cambridge cohort. Journal of Diabetes Science and Technology, 5 (6). pp. 1352-1362. ISSN 1932-2968

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Abstract

AIM: We reviewed the safety and efficacy of overnight closed-loop insulin delivery compared with conventional continuous subcutaneous insulin infusion (CSII) in two distinct age groups with type 1 diabetes mellitus (T1DM), young people aged 5 to 18 years and adults, combining data of previously published randomized studies.  METHODS: We evaluated four randomized crossover studies in 17 children and adolescents [13.4 ± 3.6 years; mean ± standard deviation (SD)] and 24 adults (37.5 ± 9.1 years) on 45 closed-loop (intervention) and 45 CSII (control) visits. Each subject attended for two overnight study visits, using either closed-loop or conventional pump therapy, in random order. In each age group, studies were designed to mimic realistic likely scenarios. In the children and adolescent studies, closed loop was used following a standard evening meal and following 40 min of moderate-intensity exercise. In the adult studies, closed loop was commenced following a 60 g carbohydrate meal or a 100 g carbohydrate meal accompanied by alcohol. The primary outcome measure was time for which plasma glucose was within target range (3.91-8.0 mmol/liter).  RESULTS: Overnight closed loop increased the time in target plasma glucose in both young (from 40% to 60%, p = .002) and adults (from 50% to 76%, p < .001) compared with conventional CSII. Combined analysis showed an increase from 43% to 71% with closed loop (p < .001). Additionally, closed loop reduced the time spent below 3.91 mmol/liter and above 8.0 mmol/liter, from 4.1% to 2.1% (p = .01) and 33% to 20% (p = .03), respectively. Glycemic variability, as measured by the SD of plasma glucose, was lower during closed loop compared with CSII (1.5 versus 2.1 mmol/liter, p = .007).  CONCLUSIONS: Overnight closed loop may improve glycemic control and reduce nocturnal hypoglycemia in both young people and adults with T1DM.

Item Type:	Article
Additional Information:	© 2011 Diabetes Technology Society.
Uncontrolled Keywords:	adolescent,adult,algorithms,blood glucose,child,cohort studies,cross-over studies,type 1 diabetes mellitus,female,humans,hypoglycemic agents,insulin,insulin infusion systems,male,randomized controlled trials as topic,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science > School of Environmental Sciences
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	25 May 2016 16:01
Last Modified:	19 Oct 2023 01:42
URI:	https://ueaeprints.uea.ac.uk/id/eprint/59064
DOI:	10.1177/193229681100500606

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