On-demand, magnetic hyperthermia-triggered drug delivery:Optimisation for the GI tract

Che Rose, Laili, Bear, Joseph C., Southern, Paul, McNaughter, Paul D., Piggott, R. Ben, Parkin, Ivan P., Qi, Sheng ORCID: https://orcid.org/0000-0003-1872-9572, Hills, Brian P. and Mayes, Andrew G. (2016) On-demand, magnetic hyperthermia-triggered drug delivery:Optimisation for the GI tract. Journal of Materials Chemistry B, 4 (9). pp. 1704-1711. ISSN 2050-750X

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Abstract

An orally-administered vehicle for targeted, on-demand drug delivery to the gastrointestinal (GI) tract is highly desirable due to the high incidence of diseases of that organ system and harsh mechanical and physical conditions any such drug delivery vehicle has to endure. To that end, we present an iron oxide nanoparticle/wax composite capsule coating that protects the capsule contents from the highly variable chemical conditions of the GI tract. It can be triggered using magnetic hyperthermia initiated from an external AC magnetic field. The coating is produced from pharmaceutically approved materials and is applied using a simple dip-coating process using a gelatin drug capsule as a template. We show that the coating is impervious to chemical conditions found within the GI tract, but is completely melted within two minutes of magnetically-induced heating under biologically-relevant conditions of temperature, pH, buffer and external field strength, allowing the delivery and dispersal of the capsule contents. The overall simplicity of action, durability and non-toxic and inexpensive nature of our drug delivery vehicle demonstrated herein are key for successful drug delivery systems for the kinds of focal therapy being sought for modern precision medicine.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry Faculty of Science > School of Pharmacy
UEA Research Groups:	Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter Faculty of Science > Research Groups > Physical and Analytical Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemistry of Materials and Catalysis
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	Pure Connector
Date Deposited:	14 Apr 2016 08:33
Last Modified:	22 Oct 2022 01:00
URI:	https://ueaeprints.uea.ac.uk/id/eprint/58223
DOI:	10.1039/c5tb02068a

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