In-vitro activity of eravacycline against carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii

Livermore, David M., Mushtaq, Shazad, Warner, Marina and Woodford, Neil (2016) In-vitro activity of eravacycline against carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, 60 (6). pp. 3840-3844. ISSN 0066-4804

[img] Microsoft Word (Manuscript) - Submitted Version
Download (53kB)

Abstract

Eravacycline and comparators were tested against carbapenem- and tigecycline-resistant Enterobacteriaceae and Acinetobacter received at the United Kingdom's national reference laboratory Eravacycline MICs correlated closely with those of tigecycline but mostly were around two-fold lower; both molecule retained full activity against isolates with high-level tetracycline and minocycline resistance. MIC90s of eravacycline and tigecycline were raised ca. two-fold for carbapenem-resistant Enterobacteriaceae compared with carbapenem-susceptible controls, probably reflecting subsets of isolates with increased efflux.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 01 Apr 2016 12:01
Last Modified: 31 Oct 2019 14:50
URI: https://ueaeprints.uea.ac.uk/id/eprint/58086
DOI: 10.1128/AAC.00436-16

Actions (login required)

View Item View Item