In-vitro activity of eravacycline against carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii

Livermore, David M., Mushtaq, Shazad, Warner, Marina and Woodford, Neil (2016) In-vitro activity of eravacycline against carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, 60 (6). pp. 3840-3844. ISSN 0066-4804

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Abstract

Eravacycline and comparators were tested against carbapenem- and tigecycline-resistant Enterobacteriaceae and Acinetobacter received at the United Kingdom's national reference laboratory Eravacycline MICs correlated closely with those of tigecycline but mostly were around two-fold lower; both molecule retained full activity against isolates with high-level tetracycline and minocycline resistance. MIC90s of eravacycline and tigecycline were raised ca. two-fold for carbapenem-resistant Enterobacteriaceae compared with carbapenem-susceptible controls, probably reflecting subsets of isolates with increased efflux.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	Pure Connector
Date Deposited:	01 Apr 2016 12:01
Last Modified:	23 Oct 2025 03:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/58086
DOI:	10.1128/AAC.00436-16

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