Clostridium difficile toxin in adult inpatients in an urban hospital in Malawi: Associations with HIV status, CD4 count and diarrhoea

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Beadsworth, Michael, Beeley, Alex, Roberts, Paul, Farragher, Brian, Watson, Alastair ORCID: https://orcid.org/0000-0003-3326-0426 and Beeching, Nick (2014) Clostridium difficile toxin in adult inpatients in an urban hospital in Malawi: Associations with HIV status, CD4 count and diarrhoea. International Journal of Tropical Medicine, 9 (1). pp. 7-9. ISSN 1818-779X

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Abstract

Clostridium difficile Infection (CDI) is the cause of substantial morbidity and mortality in the developed world. However, very little is known about the burden of CDI in sub-Saharan Africa where less antibiotic restriction, high HIV prevalence and greater impact from nosocomial infection mean the potential for a significant disease burden is great. Researchers investigated the prevalence of Clostridium difficile Toxin (CDT), assessing association with HIV, CD4 count and diarrhoea in medical in-patients in Malawi. In 206 patients tested for CDT, 28 (13.6%) were positive. No significant associations were seen with either diarrhoea or HIV. There was a non-statistically significant (p = 0.056) association between CD4 counts of <50 and CDT. The frequency and the clinical implications of CDI in both HIV positive and negative patients in sub-Saharan Africa, requires further assessment.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Related URLs:	http://medwelljournals.com/abstract/?doi...
Depositing User:	Pure Connector
Date Deposited:	01 Apr 2016 10:10
Last Modified:	04 Mar 2024 17:29
URI:	https://ueaeprints.uea.ac.uk/id/eprint/58032
DOI:	10.3923/ijtmed.2014.7.9

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