Ischemia and infarction in STEMI patients with multivessel disease: Insights from the CvLPRIT Nuclear Substudy

Kelion, Andrew D., Pakkal, Mini V., Chowdhury, Fahmid U., Birchall, James D., Dixon, Katherine L., Lai, Florence Y., Kelly, Damian J., Flather, Marcus, McCann, Gerry P. and Gershlick, Anthony H. (2016) Ischemia and infarction in STEMI patients with multivessel disease: Insights from the CvLPRIT Nuclear Substudy. Journal of the American College of Cardiology, 67 (22). pp. 2698-2699. ISSN 0735-1097

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Abstract

The CvLPRIT (Complete versus Lesion-only PRimary PCI Trial) trial was undertaken in 7 UK centers (1,2). Patients with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary stenoses were randomized to primary percutaneous coronary intervention (PPCI) to the infarct-related artery (IRA) only, or complete revascularization. At 12-month follow-up, the rate of the combined primary endpoint (all-cause mortality, recurrent MI, heart failure, ischemia-driven revascularization) was lower after complete revascularization. All surviving patients were asked to undergo myocardial perfusion scintigraphy (MPS) 6 to 8 weeks post-admission. It was expected that this a priori nuclear substudy would provide mechanistic insights into the outcome of the main trial, and help to define the clinical role of MPS in the PPCI era.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Depositing User:	Pure Connector
Date Deposited:	22 Mar 2016 09:39
Last Modified:	22 Oct 2022 00:56
URI:	https://ueaeprints.uea.ac.uk/id/eprint/57834
DOI:	10.1016/j.jacc.2016.03.544

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