Recent developments in micro- and nanofabrication techniques for the preparation of amorphous pharmaceutical dosage forms

Qi, Sheng and Craig, Duncan (2016) Recent developments in micro- and nanofabrication techniques for the preparation of amorphous pharmaceutical dosage forms. Advanced Drug Delivery Reviews, 100. pp. 67-84. ISSN 0169-409X

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Abstract

Nano- and microfabrication techniques have been widely explored in the textile, polymer and biomedical arenas, although more recently these systems have attracted considerable interest as drug delivery vehicles with concomitant considerations of physical characterization, scalability, stability and drug release. In this review, the current thinking with regards to the manufacture of solid amorphous pharmaceutical materials using electrohydrodynamic and gyration-based approaches, melt-spinning approaches, thermal moulding, inkjet printing and 3D printing will be examined in the context of their potential and actual viability as dosage forms. A series of practical examples will be discussed as to how these approaches have been used as means of producing drug delivery systems for a range of delivery systems and treatments.

Item Type: Article
Uncontrolled Keywords: micro- and nano-fabrication,electrospinning,electrospraying,pressure gyration,thermal moulding,inkect printing,3d extrusion-based printing
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Pure Connector
Date Deposited: 22 Mar 2016 09:19
Last Modified: 31 Oct 2019 14:44
URI: https://ueaeprints.uea.ac.uk/id/eprint/57714
DOI: 10.1016/j.addr.2016.01.003

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