Combining two-directional synthesis and tandem reactions. Part 4: A concise approach to the spirocyclic core of halichlorine and the pinnaic acids

Arini, Louise G., Szeto, Peter, Hughes, David L. and Stockman, Robert A. (2004) Combining two-directional synthesis and tandem reactions. Part 4: A concise approach to the spirocyclic core of halichlorine and the pinnaic acids. Tetrahedron Letters, 45 (45). pp. 8371-8374. ISSN 0040-4039

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Abstract

A synthesis of the spirocyclic core structure of halichlorine, an inhibitor of the induced expression of VCAM-1 and the pinnaic acids, inhibitors of PLA2, is presented. A two-directional strategy is employed, in conjunction with a tandem oxime formation/Michael addition/cycloaddition to form the key azaspirocyclic skeleton in a very direct manner.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry
Depositing User:	Pure Connector
Date Deposited:	11 Jan 2016 12:00
Last Modified:	07 Mar 2023 11:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/56172
DOI:	10.1016/j.tetlet.2004.09.058

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