Preparation and characterisation of ultra-fast dissolving orodispersible films for treating and preventing iodine deficiency in the paediatric population

Rustemkyzy, Cholpon, Belton, Peter and Qi, Sheng ORCID: https://orcid.org/0000-0003-1872-9572 (2015) Preparation and characterisation of ultra-fast dissolving orodispersible films for treating and preventing iodine deficiency in the paediatric population. Journal of Agricultural and Food Chemistry, 63 (44). pp. 9831-9838. ISSN 0021-8561

Microsoft Word (KIO3 fiber_numbering from abstract revised_Ch) - Accepted Version Download (7MB)

Abstract

Iodine deficiency is a public health problem that is easily prevented in many countries through having a salt iodization programme. However, the World Health Organisation (WHO) recommends that particular population groups including infants and young children have a higher daily iodine dose than adults, whilst also reducing salt consumption in their diet. Whilst many iodine supplements are available, swallowing tablet supplements is physically difficult for young children, thus there is a need for the development of novel iodine delivery systems for paediatric patients. In this study a novel, ultra-fast dissolving, nanofiber based orodispersible film iodine delivery system manufactured using an electrospinning technique was developed. The potassium iodate (KIO3) loaded poly (ethylene oxide) (PEO) fibre orodispersible films dissolve within seconds on wetting (applying on the tongue) without the need of water consumption. The electrospinning process and KIO3 loading did not alter the crystallinity and conformation of PEO. With high loading, KIO3 nanocrystals present in the fibers. This formulation design allows easy administration of iodine for preventing childhood iodine deficiency. It has also described a novel and easy method for producing and harvesting nanocrystals of inorganic salts that can be potentially adopted for use in other relevant fields.

Item Type:	Article
Uncontrolled Keywords:	iodine deficiency,electrospinning,solid dispersions,nanocrystals,ultra-fast dissolving orodispersible film ,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024) Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Biophysical Chemistry (former - to 2017) Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
Depositing User:	Pure Connector
Date Deposited:	01 Dec 2015 07:29
Last Modified:	27 Nov 2024 10:15
URI:	https://ueaeprints.uea.ac.uk/id/eprint/55539
DOI:	10.1021/acs.jafc.5b03953

Downloads

Actions (login required)

View Item