Atypical neural responses during face processing in female adolescents with conduct disorder

Fairchild, Graeme, Hagan, Cindy C, Passamonti, Luca, Walsh, Nicholas D ORCID: https://orcid.org/0000-0002-8195-7933, Goodyer, Ian M and Calder, Andrew J (2014) Atypical neural responses during face processing in female adolescents with conduct disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 53 (6). pp. 677-687. ISSN 0890-8567

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Abstract

OBJECTIVE: Conduct disorder (CD) in females is associated with negative adult outcomes including mental health problems and personality disorders. Although recent neuroimaging studies have reported changes in neural activity during facial emotion processing in males with CD or callous-unemotional (CU) traits, there have been no neuroimaging studies specifically assessing females with CD. We addressed this gap by investigating whether female adolescents with CD show atypical neural activation when processing emotional or neutral faces. METHOD: We acquired functional magnetic resonance imaging (fMRI) data from 20 female adolescents with CD and 20 female control participants while they viewed angry, sad, and neutral faces. RESULTS: An omnibus group (CD, control) by facial emotion (angry, sad, neutral) analysis of variance (ANOVA) revealed main effects of facial emotion in superior temporal cortex, fusiform gyrus, ventrolateral prefrontal cortex and insula, and main effects of group in medial orbitofrontal cortex (OFC) and right anterior insula. Female participants with CD showed reduced medial OFC and increased anterior insula responses relative to healthy controls. There were no significant group × facial emotion interactions. Lifetime CD symptoms were negatively correlated with amygdala, superior temporal cortex, fusiform gyrus, and dorsolateral prefrontal cortex activity for the contrast "all-faces versus fixation." CU traits were negatively correlated with fusiform gyrus activity for the contrast sad versus neutral faces. CONCLUSION: Females with CD showed atypical neural activation during the processing of all facial expressions, irrespective of valence. Our results demonstrate that severity of CD symptoms and CU traits is important in explaining abnormal patterns of neural activity.

Item Type:	Article
Additional Information:	Copyright © 2014 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.
Uncontrolled Keywords:	adolescent,amygdala,cerebral cortex,conduct disorder,emotions,facial expression,female,humans,magnetic resonance imaging,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Social Sciences > School of Psychology
UEA Research Groups:	Faculty of Social Sciences > Research Groups > Developmental Science Faculty of Social Sciences > Research Groups > Cognition, Action and Perception
Depositing User:	Pure Connector
Date Deposited:	30 Oct 2015 14:00
Last Modified:	21 Oct 2022 02:32
URI:	https://ueaeprints.uea.ac.uk/id/eprint/54963
DOI:	10.1016/j.jaac.2014.02.009

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