Precise relaxation time measurements of normal-appearing white matter in inflammatory central nervous system disease

Miller, D. H., Johnson, G., Tofts, P. S., Macmanus, D. and McDonald, W. I. (1989) Precise relaxation time measurements of normal-appearing white matter in inflammatory central nervous system disease. Magnetic Resonance in Medicine, 11 (3). pp. 331-336. ISSN 0740-3194

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Abstract

Precise relaxation time (RT) measurements have been made, with a standard deviation of 3% for T1 and T2 in white matter in normal volunteers. This sets an upper limit to the instrumental random errors (imprecision). Achieving this precision requires careful adjustment and use of the imager. The wide variation in RTs seen by other workers may be in part due to larger instrumental errors. We have measured RTs (both T1 and T2) in normal-appearing white matter in 16 normal controls and patients with multiple sclerosis (MS, 18), systemic lupus erythematosis (SLE, 16) and cerebral sarcoidosis (8). Both RTs were significantly higher in MS than in other patient groups and controls (P less than .05), possibly caused by microscopic lesions. T2 was elevated in SLE patients relative to controls and sarcoidosis patients (P less than .05), possibly because of microhemorrhages. Lesion RTs were abnormal but more variable and no significant differences between diseases were found.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Depositing User:	Pure Connector
Date Deposited:	06 Oct 2015 14:00
Last Modified:	21 Oct 2022 01:19
URI:	https://ueaeprints.uea.ac.uk/id/eprint/54611
DOI:	10.1002/mrm.1910110307

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